Eukaryote-specific rRNA expansion segments function in ribosome biogenesis
نویسندگان
چکیده
منابع مشابه
Yeast rRNA Expansion Segments: Folding and Function.
Divergence between prokaryotic and eukaryotic ribosomal RNA (rRNA) and among eukaryotic ribosomal RNAs is focused in expansion segments (ESs). Eukaryotic ribosomes are significantly larger than prokaryotic ribosomes partly because of their ESs. We hypothesize that larger rRNAs of complex organisms could confer increased functionality to the ribosome. Here, we characterize the binding partners o...
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The poly-A specific ribonuclease (PARN), initially characterized for its role in mRNA catabolism, supports the processing of different types of non-coding RNAs including telomerase RNA. Mutations in PARN are linked to dyskeratosis congenita and pulmonary fibrosis. Here, we show that PARN is part of the enzymatic machinery that matures the human 18S ribosomal RNA (rRNA). Consistent with its nucl...
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ژورنال
عنوان ژورنال: RNA
سال: 2016
ISSN: 1355-8382,1469-9001
DOI: 10.1261/rna.056705.116